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Published on: July 1, 2020
[Clinical epidemiology of fungal infection in diabetes]
1Division of Diabetes and Endocrinology, Department of Internal Medicine, Saiseikai Yokohamashi Tobu Hospital.
Abstract:
It is well-known that diabetes is a risk for infection. According to our analysis of the cause of death in 221 diabetic patients over 10 years, infection and pneumonia accounted for 22% of all deaths. Diabetes may increase the risk of mycotic infections; however, few data are available on the prevalence of fungal infections in diabetic patients. The purpose of this paper was to analyze the clinical epidemiology of fungal infections in diabetic patients. Onychomycosis, oral candidiasis and vulvovaginal candidiasis are observed frequently in diabetic patients. Urinary tract candidiasis in diabetic patients frequently develops into systemic candidiasis and fungus ball formation in the kidney. An estimated 50-75% of cases of rhinocerebral mucomycosis occur in diabetic patients, and ketoacidosis is thought to be the most likely predisposing factor. Invasive otitis externa is almost exclusively found in diabetic patients, and generally caused by Pseudomonas. This has been described secondary to Aspergillus in diabetic patients. Regarding cryptococcosis in non-AIDS patients, approximately 10 to 20% of these patients have diabetes. Clinicians must be aware of mycotic infection in diabetic patients with infectious disease.
Insights
Diabetes significantly increases the risk of fungal infections, including common conditions like onychomycosis and candidiasis. Awareness is crucial as these infections can lead to severe complications in diabetic individuals.
Area of Science:
- Infectious Diseases
- Endocrinology
- Mycology
Context:
- Diabetes mellitus is a well-established risk factor for various infections.
- Infections, including pneumonia, account for a significant portion of mortality in diabetic patients.
- Limited data exist on the prevalence and clinical epidemiology of fungal infections in this population.
Purpose:
- To analyze the clinical epidemiology of fungal infections in patients with diabetes.
- To highlight the common types and potential severity of mycotic infections in diabetics.
- To raise clinician awareness regarding fungal infections in diabetic patients.
Summary:
- Fungal infections such as onychomycosis, oral and vulvovaginal candidiasis are frequent in diabetics.
- Diabetic patients are prone to severe fungal infections like urinary tract candidiasis, rhinocerebral mucomycosis, and invasive otitis externa.
- Diabetes is also a notable comorbidity in non-AIDS cryptococcosis cases.
Impact:
- Underscores the importance of recognizing and managing fungal infections in diabetic patients.
- Suggests that diabetic ketoacidosis is a key predisposing factor for certain severe fungal infections.
- Emphasizes the need for heightened clinical vigilance for mycotic infections in diabetic individuals presenting with infectious diseases.
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