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Updated: Jun 27, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
Published on: April 19, 2017
[Imaging of fungal infection in diabetic patients]
Kazuto Ashizawa1, Aya Fukushima, Masataka Uetani
1Clinical Oncology Center, Nagasaki University Hospital.
Abstract:
Diabetes mellitus is an important risk factor for infections caused by fungi. Candidiasis is the most frequent fungal infection in diabetic patients, followed by aspergillosis, cryptococcosis, and mucormycosis. Fungal infection is a serious cause of morbidity and mortality in immunocompromised hosts. Diagnostic imaging plays an important role in the early diagnosis and treatment for these infections, especially for the pulmonary infection. Although imaging findings of pulmonary fungal infection are various, ground-glass opacity surrounding nodules or masses called "CT halo sign" is a relatively characteristic finding. In this review, we discuss the imaging finding of fungal infection particularly focusing on the pulmonary lesions.
Insights
Diabetes increases the risk of fungal infections like candidiasis. This review highlights the CT halo sign as a key imaging finding for diagnosing pulmonary fungal infections in diabetic patients.
Area of Science:
- Medical Mycology
- Radiology
- Infectious Diseases
Background:
- Diabetes mellitus is a significant risk factor for invasive fungal infections.
- Diabetic patients are susceptible to various fungal infections, including candidiasis, aspergillosis, cryptococcosis, and mucormycosis.
- Fungal infections pose a serious threat, leading to increased morbidity and mortality, particularly in immunocompromised individuals.
Purpose of the Study:
- To review the characteristic imaging findings of fungal infections in diabetic patients.
- To emphasize the role of diagnostic imaging in the early detection and management of pulmonary fungal infections.
- To focus on the significance of the CT halo sign in identifying pulmonary fungal lesions.
Main Methods:
- Review of literature on fungal infections in diabetic patients.
- Analysis of diagnostic imaging findings, particularly computed tomography (CT) scans.
- Focus on characteristic radiological signs, such as the CT halo sign.
Main Results:
- Fungal infections are common and serious complications in patients with diabetes mellitus.
- Diagnostic imaging is crucial for the timely diagnosis of these infections, especially pulmonary forms.
- The CT halo sign, characterized by ground-glass opacity surrounding nodules or masses, is a relatively specific finding for pulmonary fungal infections.
Conclusions:
- Early diagnosis and treatment of fungal infections in diabetic patients are critical for improving outcomes.
- Radiological assessment, with attention to specific signs like the CT halo sign, aids in the prompt identification of pulmonary fungal disease.
- Understanding these imaging patterns is essential for clinicians managing diabetic patients at risk of fungal infections.
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