Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molar Mass01:54

Molar Mass

The identity of a substance is defined not only by the types of atoms or ions it contains but by the quantity of each type of atom or ion. For example, water, H2O, and hydrogen peroxide, H2O2, are alike in that their respective molecules are composed of hydrogen and oxygen atoms. However, because a hydrogen peroxide molecule contains two oxygen atoms, as opposed to the water molecule, which has only one, the two substances exhibit very different properties.
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For example, the mass of helium...
Dosage Regimen: Multiple Oral Dosage01:25

Dosage Regimen: Multiple Oral Dosage

Understanding how a drug's concentration fluctuates within the body over time is crucial in pharmacokinetics, particularly with multiple oral doses. A graphical representation of multiple oral dosages provides insight into these dynamics. Typical accumulation curves of a drug's concentration in the body reveal a sawtooth pattern, indicating periodic peaks and troughs correlating with each dose administration and the drug's subsequent elimination.The plasma concentration at any time during an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of long-term equine herpesvirus type 1 (EHV-1) infection on primary murine neurons-the possible effects of the multiple passages of EHV-1 on its neurovirulence.

Folia microbiologica·2017
Same author

Replication kinetics of neuropathogenic and non-neuropathogenic equine herpesvirus type 1 (EHV-1) strains in primary murine neurons and ED cell line.

Polish journal of veterinary sciences·2017
Same author

Equid herpesvirus type 1 (EHV-1) disrupts actin cytoskeleton during productive infection in equine leukocytes.

Polish journal of veterinary sciences·2015
Same author

Systematic review with meta-analysis: early infant feeding and coeliac disease--update 2015.

Alimentary pharmacology & therapeutics·2015
Same author

Meta-analysis: Lactobacillus reuteri strain DSM 17938 (and the original strain ATCC 55730) for treating acute gastroenteritis in children.

Beneficial microbes·2014
Same author

Equine herpesvirus type 1 (EHV-1)-induced rearrangements of actin filaments in productively infected primary murine neurons.

Archives of virology·2013

Related Experiment Video

Updated: Jun 27, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Mass versus molar doses, similarities and differences.

A Chmielewska1, H Lamparczyk

  • 1Medical University of Gdansk, Faculty of Pharmacy, Hallera 107, 80 416 Gdansk, Poland. chmola@amg.gda.pl

Die Pharmazie
|December 17, 2008
PubMed
Summary

This study compares mass dose and molar dose systems for drugs. Molar dose better describes differences between drug groups and within different dosages of the same drug.

Area of Science:

  • Pharmacology
  • Pharmaceutical Sciences
  • Drug Dosage Systems

Background:

  • Drug quantities are expressed using mass (grams, milligrams) or molar dose (number of molecules).
  • The mass-based system is currently prevalent in pharmaceutical practice.
  • Understanding the relationship between mass and molar dose is crucial for accurate drug comparison.

Purpose of the Study:

  • To compare the advantages and disadvantages of mass dose versus molar dose systems.
  • To evaluate which dosage system better represents inter- and intra-group variations in drug substances.
  • To analyze various drug classes, including single and multiple active ingredient products.

Main Methods:

  • Calculated molar doses from mass doses and molar masses for selected active substances.

More Related Videos

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Related Experiment Videos

Last Updated: Jun 27, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator
07:31

Characterization of Recombination Effects in a Liquid Ionization Chamber Used for the Dosimetry of a Radiosurgical Accelerator

Published on: May 9, 2014

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

  • Considered diverse drug categories: antibiotics, nootropics, beta-blockers, vitamins, and more.
  • Analyzed drug products with single and multiple active ingredients, including specific combinations like hydrochlorothiazide mixtures and oral contraceptives.

    • Main Results:

    • Molar dose calculations were performed for a wide range of pharmaceuticals.
    • Comparisons were made across drug groups with similar pharmacological activities and pharmaceutical alternatives.
    • The study utilized theoretical equations and derived relationships to support the data analysis.

    Conclusions:

    • The molar dose system offers a more adequate description of differences between and within drug groups compared to the mass dose system.
    • This finding has implications for pharmaceutical analysis, drug development, and clinical practice.
    • Further research can explore the clinical utility of molar dosing in various therapeutic areas.