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[Determine and parallel analysis of three kinds of PAEs in serum for obese children]
Ping Li1, Xingbi Dai, Hong Dan
1School of Public Health, Chongqing University of Medical Sciences, Chongqing 400016, China.
Insights
Obese children aged 10-12 show higher serum levels of certain phthalate esters (PAEs), specifically dibutyl phthalate (DBP) and diethylhexyl phthalate (DEHP). This suggests PAEs may contribute to health issues in obese youth.
Area of Science:
- Environmental health
- Pediatric endocrinology
- Analytical chemistry
Context:
- Phthalate esters (PAEs) are common endocrine-disrupting chemicals.
- Childhood obesity is a growing global health concern.
- Exposure to PAEs is widespread, with potential health implications.
Purpose:
- To quantify and compare serum concentrations of specific PAEs (DEP, DBP, DEHP) in obese versus normal-weight children aged 10-12 years.
- To assess the association between obesity and elevated PAE levels in this pediatric cohort.
- To evaluate the potential harm of PAEs in obese children.
Summary:
- Serum samples from 36 obese and 36 normal-weight children were analyzed for DEP, DBP, and DEHP using RP-HPLC.
- Significantly higher median serum levels of DBP and DEHP were found in obese children compared to normal-weight children (P < 0.01).
- Obese children exhibited higher proportions of individuals with elevated PAE levels.
Impact:
- Findings indicate a significant correlation between childhood obesity and increased exposure to DBP and DEHP.
- This study highlights the potential health risks associated with PAE exposure in the context of pediatric obesity.
- Results underscore the need for further research into PAE toxicity and preventative strategies in vulnerable pediatric populations.
Objective:
To study the serum contents of the PAEs of obese children at the ages of 10 to 12 years, in order to estimate the harm of PAEs on obese children.
Methods:
The contents of three kinds PAEs(DEP, DBP and DEHP) in the serum for two groups of children, including 36 obese children and 36 normal weight children, were determined by the reversed phase high performance liquid chromatography (RP-HPLC) method And the average measure value of three kind PAEs between two groups of children were analysed.
Results:
The median serum levels of PAEs were 0.0032 (DEP), 0.1649 (DBP) and 0.1680 (DEHP) in obese children. And the serum levels of PAEs were 0.0026 (DEP), 0.0359 (DBP) and 0.1063 (DEHP) in normal weight children. The differences of average measure value of DBP and DEHP in three kind PAEs between two groups of children were significant (P < 0.01). The amounts of obese children in high level were more than those of normal weight children, and the constitution ratios in three kinds of PAEs of obese children were higher than those of normal weight children. The differences between two groups of children were significant (P < 0.01).
Conclusion:
The average levels of DBP and DEHP in serum of obese children were more than those of serum of normal weight children. The amounts of obese children were higher than those of normal weight children in high level content of three kinds of PAEs.
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