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Published on: April 12, 2019
[Protective effects of nanometer selenium on acute gastric mucosal lesion in rats]
Xiaohong Yu1, Xiuju Xu, Jun Su
1Department of Nutrition and Food Hygiene, Baotou Medical College, Baotou 014010, China. yuxiaohong224@163.com
Objective:
To study the protective effects of nanometer selenium on acute gastric mucosal lesion in rats.
Methods:
50 healthy Wister rats were divided into five groups randomly: normal group, model group, and three experimental groups (4.17, 8.33 and 16.67 mg/kg). The lesion of gastric mucosal was established by giving absolute alcohol after giving nanometer selenium of different dosage to rats except normal group, examined histopathology of gastric mucosa, then measured the lesion index (UI)of rats in normal group, model group and three experimental groups. The activity of glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) content in blood were determined.
Results:
Gastric mucosal lesion index of all the three experimental groups was obviously reduced compared with the control groups (P < 0.01) and existed dose dependent. The nanometer selenium elevated GSH-Px activity (P < 0.01) but reduced MDA content (P < 0.05, P < 0.01). In addition, the extent of mucosal lesion of experimental groups was significantly less than that of experimental control.
Conclusion:
Nanometer selenium can significantly prevent absolute ethanol-induced acute gastric mucosal lesion. The mechanism may be related to the antioxidation of the powder.
