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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: February 6, 2019

PET/CT in radiation oncology.

Tinsu Pan¹, Osama Mawlawi

¹Department of Imaging Physics, M. D. Anderson Cancer Center, The University of Texas, Houston, Texas 77030, USA. tpan@mdanderson.org

Medical Physics

|December 17, 2008

Summary

Positron emission tomography/computed tomography (PET/CT) enhances cancer diagnosis, staging, and treatment planning by combining functional and anatomical imaging. Its integration into radiation therapy (RT) is crucial for improving patient outcomes.

Area of Science:

Medical Imaging
Oncology
Radiotherapy

Background:

Positron emission tomography/computed tomography (PET/CT) integrates functional PET and anatomical CT imaging, replacing conventional standalone PET for improved clinical outcomes.
PET/CT is widely adopted in oncology, with over two thousand scanners globally, primarily using Fluorine-18 deoxyglucose to assess tumor glucose uptake.
Over 50% of cancer patients undergo radiation therapy (RT), where PET/CT information significantly influences management and RT planning.

Purpose of the Study:

To review current PET/CT technology and its applications in oncology and radiation therapy.
To project future developments in PET and CT instrumentation for PET/CT.
To discuss challenges and potential improvements in PET/CT simulation for thoracic radiation therapy.

Main Methods:

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Review of current PET/CT technology and clinical applications.
Analysis of the impact of PET/CT on cancer patient management and radiation therapy planning.
Discussion of future trends in PET/CT instrumentation and simulation techniques.

Main Results:

PET/CT offers superior diagnostic and staging capabilities compared to standalone PET or CT.
PET/CT findings frequently alter patient management and radiation therapy plans.
The role of PET/CT in radiation therapy is expanding, with ongoing technological advancements.

Conclusions:

PET/CT is an essential tool in modern oncology, significantly impacting patient care and treatment planning.
Continued advancements in PET/CT technology will further enhance its integration into radiation therapy.
Optimizing PET/CT simulation, particularly for thoracic applications, is key to maximizing its benefits in RT.