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Long-term prognosis of patients with cardiac syndrome X

Priscilla Lamendola1, Gaetano A Lanza, Antonella Spinelli

  • 1Istituto di Cardiologia, Università Cattolica del Sacro Cuore, Roma, Italy.

International Journal of Cardiology
|December 17, 2008
PubMed

Insights

Patients with cardiac syndrome X (CSX) experience excellent long-term survival, with no cardiovascular deaths observed. However, many patients report persistent or worsening chest pain, necessitating ongoing medical evaluation.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Cardiac Syndrome X (CSX) prognosis was previously considered good.
  • Recent studies suggest higher mortality in patients with angina and normal coronary arteries.
  • This study investigates long-term outcomes in CSX patients.

Purpose of the Study:

  • To assess the long-term clinical prognosis of patients diagnosed with typical Cardiac Syndrome X.
  • To evaluate the incidence of major cardiac events, hospital readmissions, and symptom progression in this cohort.

Main Methods:

  • Clinical follow-up of 155 patients with typical CSX.
  • Data collection included major cardiac events, readmissions for chest pain, revascularization, angina status, and non-cardiac events.
  • Mean follow-up duration was 137 months.

Main Results:

  • No cardiovascular deaths or major cardiac events occurred during follow-up.
  • 89% of patients were readmitted for recurrent chest pain.
  • Chest pain persisted or worsened in 47% of patients, with 22% undergoing repeat coronary angiography.

Conclusions:

  • Patients with CSX demonstrate an excellent long-term clinical prognosis regarding mortality.
  • A substantial proportion of CSX patients experience persistent or worsening symptoms, requiring continued medical attention.
Abstract

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