Related Experiment Video

Updated: Jun 27, 2026

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

[Endoplasmic reticulum stress in kidney diseases: a question of life and death?]

Nicolas Pallet1, Nicolas Bouvier, Philippe Beaune

  • 1Inserm U775, centre universitaire des Saints-Pères, université Paris Descartes, 45, rue des Saints-Pères, 75006 Paris, France. nicolas.pallet@univ-paris5.fr

Nephrologie & Therapeutique
|December 17, 2008
PubMed

Insights

Endoplasmic reticulum stress, a key factor in kidney diseases, influences cell death, inflammation, and epithelial changes. Understanding this process is vital for developing new kidney injury biomarkers and therapies.

Area of Science:

  • Nephrology
  • Cellular Biology
  • Molecular Medicine

Context:

  • Kidney diseases involve complex cellular and molecular mechanisms.
  • Endoplasmic reticulum stress is increasingly implicated in various kidney insults.
  • The role of endoplasmic reticulum stress in kidney disease pathogenesis is not fully understood.

Purpose:

  • To review current data on endoplasmic reticulum stress in kidney injury.
  • To elucidate the specific role of endoplasmic reticulum stress in chronic kidney disease.

Summary:

  • Endoplasmic reticulum stress impacts cell death, inflammation, and epithelial-to-mesenchymal transition.
  • The unfolded protein response (UPR) mediates cellular dysfunction during kidney insults.
  • Experimental evidence links endoplasmic reticulum stress to a spectrum of kidney damage.

Impact:

  • Improved understanding may lead to novel biomarkers for early kidney injury detection.
  • Insights can drive the development of new therapeutic strategies for renal failure prevention and regeneration.
  • Clarifying the role of endoplasmic reticulum stress can inform future chronic kidney disease treatments.

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Role of ER in the Secretory Pathway01:17

Role of ER in the Secretory Pathway

Eukaryotic cells have a special pathway that enables communication between various intracellular membrane-bound compartments and also with the extracellular environment. This pathway is termed as the secretory pathway.
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...