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Near-infrared spectroscopy applications in pharmaceutical analysis
J Luypaert1, D L Massart, Y Vander Heyden
1Department of Analytical Chemistry and Pharmaceutical Technology, Pharmaceutical Institute, Vrije Universiteit Brussel (VUB), Laarbeeklaan 103, B-1090 Brussel, Belgium.
Talanta
|December 17, 2008
Summary
Near-infrared (NIR) spectroscopy is a versatile, non-destructive technique. This review highlights its pharmaceutical applications, from raw material analysis to final product release, including process analytical technology (PAT) and NIR imaging.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Pharmaceutical Science
Background:
- Near-infrared (NIR) spectroscopy is a rapid, non-destructive analytical method.
- It offers significant advantages across various industrial sectors.
- Its utility in pharmaceuticals spans quality control and process monitoring.
Purpose of the Study:
- To review recent advancements in pharmaceutical applications of NIR spectroscopy.
- To explore NIR spectroscopy's role in process analytical technology (PAT).
- To discuss emerging applications in NIR imaging within the pharmaceutical industry.
Main Methods:
- Literature review of recent developments in NIR spectroscopy for pharmaceuticals.
- Categorization of applications into identification, water content, assay, and other areas.
- Discussion of instrumental advancements enabling new applications.
Main Results:
- NIR spectroscopy is applicable from raw material identification to final product release.
- Its characteristics facilitate implementation as a process analytical technology (PAT).
- Recent instrumental progress expands possibilities in NIR imaging.
Conclusions:
- NIR spectroscopy is a valuable tool for pharmaceutical analysis and quality control.
- The technique supports real-time process monitoring and product release.
- NIR imaging presents promising future applications in pharmaceutical development and manufacturing.
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