A selective artemisinin-sensor using metalloporphyrin as a recognition element entrapped in the
Fu-Chun Gong1, Zi-Dan Xiao, Zhong Cao
1College of Chemistry and Environmental Engineering, Changsha University, of Science and Technology, Changsha 410076, PR China.
Abstract:
An amperometric artemisinin (ARN) sensor based on the supramolecular recognition of glycosylated metalloporphyrin, which is included in the Au-nanoparticles-chitosan film coated on the glass carbon electrodes, was developed. For the improvement of the selectivity of artemisinin detection, 5,10,15,20-tetrakis[2-(2,3,4,6-tetraacetyl-beta-d-glucopyranosyl)-1-O-phenyl]porphyrin (T(o-glu)PPH) metal complex [FeT(o-glu)PPCl] was synthesized and employed as a ARN-sensitive and -selective material in the amperometric sensors. The proposed [FeT(o-glu)PPCl]/Au-nanoparticles modified electrodes showed excellent selectivity and sensitivity toward ARN with respect to a number of interferents and exhibited stable current response, which can be attributed to the coordination of ARN with the [FeT(o-glu)PPCl] in the electrodes. The calibration graph obtained with the proposed sensor was linear over the range of 1.8x10(-7)-1.7x10(-9)moll(-1), with a detection limit of 1.7x10(-9)moll(-1) for ARN. Significant advantages of the proposed procedure over the conventional reductive electrochemical methods are the selective detection and the relatively low applied potential requirement of the ARN-sensor. The prepared sensor is applied for the determination of ARN in plant samples and the results agreed with the values obtained by the pharmacopoeia method.
