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Solid phase synthesis of N-alkyl-bis-o-aminobenzamides for metal ion sensing based on a fluorescent dansyl platform

G Pina-Luis1, A Ochoa-Terán, I A Rivero

  • 1Graduate Center and Research of Technological Institute of Tijuana, Tijuana, B.C. México.

Journal of Combinatorial Chemistry
|December 17, 2008
PubMed

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Direct alkylation of ammonia produces polyalkylated amines, along with a quaternary ammonium salt. To exclusively prepare primary amines, the azide synthesis method can be used.
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Strong bases like NaOH or KOH deprotonate the phthalimide to form the corresponding anion, which acts as a nucleophile. Further, the anion attacks an...
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