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Updated: Aug 10, 2026

Phagosome Migration and Velocity Measured in Live Primary Human Macrophages Infected with HIV-1
Published on: September 5, 2016
HIV-p24-antigen-bearing macrophages are only present in brains of HIV-seropositive patients with AIDS-encephalopathy
1Institute of Anatomy, Westfälische Wilhelms-Universität Münster, Germany.
Abstract:
The central nervous system of HIV-seropositive patients with and without AIDS-encephalopathy was investigated by immunocytochemistry using the monoclonal antibody to the HIV-1 p24 core protein. Numerous p24-immunopositive mono- and multinucleated macrophages could only be detected in patients with typical histological pictures of an AIDS-encephalopathy. These findings allow the supposition that AIDS-dementia is a result of a relatively late infiltration of HIV-infected macrophages from the bloodstream into the brain and is not due to an impairment of neuronal and/or glial cells infected by HIV during the early stage of the disease.
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