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Related Concept Videos

Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: Jun 27, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Interview. Epigenomics, imprinting and disease susceptibility.

Randy L Jirtle

    Pharmacogenomics
    |December 17, 2008
    PubMed
    Summary

    Professor Randy L Jirtle

    Area of Science:

    • Epigenetics and genomic imprinting research.
    • Fetal origins of disease susceptibility.

    Background:

    • Professor Jirtle's academic career began in 1970, earning a BS in nuclear engineering and a PhD in radiation biology from the University of Wisconsin-Madison.
    • He has been a faculty member at Duke University since 1977, holding positions in Radiation Oncology and Pathology.

    Discussion:

    • Jirtle's research focuses on epigenetics, genomic imprinting, and how early development influences disease susceptibility.
    • He has authored over 160 peer-reviewed articles, with significant contributions highlighted on journal covers.
    • His work aims to enhance public understanding of epigenomics.

    Key Insights:

    • Created the website www.geneimprint.org, recognized as an 'Exemplary Website in Genetics'.
    • Organized five international meetings and presented research at numerous global conferences, including the 2004 Nobel Symposium on Epigenetics.

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    Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
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    Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

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    Last Updated: Jun 27, 2026

    Methylated DNA Immunoprecipitation
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    Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
    13:11

    Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

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    Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution
    13:47

    Enhanced Reduced Representation Bisulfite Sequencing for Assessment of DNA Methylation at Base Pair Resolution

    Published on: February 24, 2015

    Outlook:

    • Received multiple accolades, including the Distinguished Achievement Award (2006), an Esther B. O'Keeffe Charitable Foundation Award (2007), and the Epigenetic Medicine Award (2008).
    • Nominated for Time Magazine's 'Person of the Year' in 2007, reflecting the impact of his work.