Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

British Association of Dermatologists living guideline for managing people with nodular prurigo (prurigo nodularis) 2025.

The British journal of dermatology·2026
Same author

Skin biology and ageing.

Skin health and disease·2023
Same author

Hereditary leiomyomatosis and renal cell cancer linked with FH mutations.

Clinical and experimental dermatology·2023
Same author

Obesity-induced immunological effects on the skin.

Skin health and disease·2023
Same author

Proopiomelanocortin (POMC) and psychodermatology.

Skin health and disease·2023
Same author

A farewell from the founding Editor of Skin Health and Disease.

Skin health and disease·2023

Related Experiment Video

Updated: Jun 27, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

Epigenetics and dermatological disease.

George W M Millington1

  • 1Dermatology Department, Norfolk & Norwich University Hospitals, NHS Foundation Trust, Colney Lane, Norwich, NR4 7UZ, UK. george.millington@nnuh.nhs.uk

Pharmacogenomics
|December 17, 2008
PubMed
Summary

Epigenetics influences skin diseases by altering gene expression without changing DNA. Aberrant DNA methylation is linked to skin cancers and autoimmune conditions like lupus and scleroderma.

Area of Science:

  • Dermatology
  • Molecular Biology
  • Genetics

Background:

  • Epigenetics, the study of heritable phenotype changes without altering the genetic code, plays a crucial role in various biological processes.
  • Skin diseases, including cancers and autoimmune conditions, are increasingly understood to involve epigenetic dysregulation.
  • Environmental factors can influence epigenetic modifications, impacting disease development.

Purpose of the Study:

  • To explore the role of epigenetics in the pathogenesis of common skin diseases.
  • To investigate the association between epigenetic alterations and conditions like skin cancer, autoimmune diseases, and inflammatory skin disorders.
  • To highlight the impact of environmental factors on epigenetic mechanisms in skin disease.

Main Methods:

More Related Videos

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

Related Experiment Videos

Last Updated: Jun 27, 2026

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis
09:16

Generation of Genetically Modified Organotypic Skin Cultures Using Devitalized Human Dermis

Published on: December 14, 2015

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

  • Analysis of aberrant methylation patterns in tumor suppressor genes in skin cancers.
  • Investigation of DNA hypomethylation in systemic autoimmune diseases.
  • Review of epigenetic involvement in inflammatory skin conditions and genomic imprinting disorders.

    • Main Results:

    • Aberrant methylation of tumor suppressor gene promoters is linked to transcriptional inactivation in skin cancers.
    • DNA hypomethylation is associated with the activation of systemic autoimmune diseases, potentially via cross-reactivity with bacterial DNA.
    • Epigenetic factors are implicated in the pathogenesis of psoriasis, other inflammatory skin diseases, and genomic imprinting disorders with cutaneous manifestations.

    Conclusions:

    • Epigenetic mechanisms, particularly DNA methylation, are critical in the development and progression of diverse skin diseases.
    • Understanding these epigenetic alterations offers potential therapeutic targets for skin cancer, autoimmune, and inflammatory conditions.
    • Environmental exposures can trigger epigenetic changes contributing to skin pathology.