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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Gene-Environment Interactions01:20

Gene-Environment Interactions

Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...

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Related Experiment Video

Updated: Jun 27, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Epigenetics and obesity.

Reinhard Stöger1

  • 1Department of Biology, University of Washington, 156 Kincaid Hall, Box 351800, Seattle, WA, 98195-1800, USA. stoeger@u.washington.edu

Pharmacogenomics
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Imprinted genes, crucial for development, may influence obesity but require further study. Advanced sequencing methods are needed to detect subtle epigenetic variations linked to body weight in the general population.

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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
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Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Related Experiment Videos

Last Updated: Jun 27, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
13:09

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Area of Science:

  • Genetics
  • Epigenetics
  • Obesity Research

Background:

  • Genetic variations alone do not fully explain differences in individual body fat.
  • Certain imprinted gene disorders are linked to abnormal body weight.
  • The role of imprinted genes in general population obesity remains unclear.

Purpose of the Study:

  • To explore the potential relevance of imprinted genes and epigenetics in obesity.
  • To identify challenges and necessary approaches for studying epigenetics in obesity.

Main Methods:

  • The study highlights the need for genome-wide, next-generation sequencing.
  • These advanced methods are required to detect epigenetic differences.

Main Results:

  • Common DNA variants are insufficient to explain fat mass variability.
  • Imprinted genes and epigenetic mosaicism present challenges in this research area.
  • Subtle epigenetic variations in imprinted genes and networks likely exist across individuals.

Conclusions:

  • Imprinted genes are implicated in obesity, but their population-level relevance needs investigation.
  • Detecting subtle epigenetic differences using advanced sequencing is crucial for future obesity research.