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SEN Virus infection in HIV/HCV coinfected patients

A Sagir1, O Adams, M Oette

  • 1Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinik Düsseldorf, Moorenstr. 5, 40225 Düsseldorf, Germany. sagir@med.uni-duesseldorf.de

European Journal of Medical Research
|December 17, 2008
PubMed

Insights

Hepatitis C Virus (HCV) coinfection in HIV patients does not affect treatment outcomes. SEN Virus (SENV) replication is lower in HIV/HCV coinfected individuals, but SENV presence does not alter HCV therapy effectiveness.

Area of Science:

  • Virology
  • Infectious Diseases
  • Immunology

Background:

  • Chronic Hepatitis C Virus (HCV) infection is a significant coinfection in HIV-positive individuals.
  • The impact of SEN Virus (SENV) on HCV treatment outcomes in coinfected patients is not well understood.

Purpose of the Study:

  • To investigate the prevalence of SENV DNA in different patient groups.
  • To determine the influence of SENV on HCV treatment response in HIV/HCV coinfected patients receiving combination therapy.

Main Methods:

  • Polymerase chain reaction (PCR) was used to detect SENV DNA in 67 HIV/HCV coinfected patients, 77 HIV monoinfected patients, 95 HCV monoinfected patients, and 122 healthy donors.
  • Quantitative analysis of SENV H DNA levels was performed.

Main Results:

  • SENV DNA was detected in 12% of HIV/HCV coinfected patients, 11.7% of HIV monoinfected patients, 22% of HCV monoinfected patients, and 9.8% of healthy donors.
  • Mean SENV H DNA levels were significantly lower in HIV/HCV coinfected patients compared to other groups.
  • Sustained virological response rates to HCV therapy did not differ between SENV-positive and SENV-negative HIV/HCV coinfected patients (62.5% vs. 47.5%).

Conclusions:

  • Hepatitis C Virus (HCV) coinfection may suppress SEN Virus (SENV) replication in HIV-positive individuals, leading to lower SENV H DNA levels.
  • SEN Virus (SENV) infection does not appear to influence the outcome of combination therapy for Hepatitis C Virus (HCV) in coinfected patients.
Abstract

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