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Updated: Jun 27, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
[Relationships between copy number variations and human disease and its perspective in animal disease-resistant
Yang-Hua He1, Ying Yu, Yuan Zhang
1College of Animal Science and Technology, China Agricultural University, Beijing 100193, China. hyh19831205 @163.com
Abstract:
Copy number variations (CNVs) refer to the deletion, insertion, and duplication of genes over 1 kb in length. CNVs were widely found in human and other mammalian genomes. Here, we mainly reviewed the impacts of CNVs on the human diseases, and introduced the general detecting methods for CNVs. We also discussed the potential relationship between CNVs and disease-resistant breeding of animals. Because of the significant effects of CNVs on the resistance and susceptibility of disease, CNVs can be used in the marker-assisted selection, QTL fine mapping, and disease-resistant breeding of livestocks by means of biotechnologies.
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