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Related Experiment Videos

Morphine-6-glucuronide: effects on ventilation in normal volunteers.

S J Peat1, M H Hanna, M Woodham

  • 1Pain Relief Research Unit, London SE5 9RS U.K. Academic Department of Anaesthetics, King's College School of Medicine and Dentistry, London SE5 9RS U.K.

Pain
|April 1, 1991
PubMed
Summary

Morphine and its metabolite, morphine-6-glucuronide (M6G), affect respiratory function. Morphine significantly increased end-tidal CO2 and reduced ventilatory response to carbon dioxide, while M6G had a lesser impact.

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Area of Science:

  • Pharmacology
  • Respiratory Physiology

Background:

  • Opioids like morphine are known to depress respiratory function.
  • Morphine-6-glucuronide (M6G) is a major active metabolite of morphine, but its respiratory effects are less understood.

Purpose of the Study:

  • To compare the respiratory effects of intravenous morphine sulphate and its metabolite, M6G, in healthy volunteers.
  • To assess the dose-dependent effects of M6G on respiratory control.

Main Methods:

  • A single-blind, randomized crossover study involving 6 healthy volunteers.
  • Continuous measurement of respiratory rate, minute volume, and end-tidal CO2.
  • Assessment of ventilatory response to carbon dioxide challenges before and after drug administration.

Main Results:

Related Experiment Videos

  • Morphine administration led to a significant increase in end-tidal CO2 and a reduced ventilatory response to CO2.
  • M6G (at both 0.03 mg/kg and 0.06 mg/kg) also reduced the ventilatory response to CO2, but to a lesser extent than morphine.
  • No significant change in end-tidal CO2 was observed after placebo or M6G administration.

Conclusions:

  • Intravenous morphine significantly depresses respiratory drive.
  • Morphine-6-glucuronide exhibits less potent respiratory depressant effects compared to morphine.
  • The metabolite M6G contributes to the overall respiratory profile of morphine, but morphine itself is the primary driver of significant respiratory depression.