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Gap junctional intercellular communication in the juxtaglomerular apparatus
Jian Yao1, Takashi Oite, Masanori Kitamura
1Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi 409-3898, Japan. yao@yamanashi.ac.jp
American Journal of Physiology. Renal Physiology
|December 17, 2008
Summary
Gap junctions in the juxtaglomerular apparatus (JGA) coordinate cell functions for blood pressure control. Intercellular calcium (Ca2+) signals mediated by gap junctions are crucial for JGA physiological responses.
Area of Science:
- Nephrology
- Physiology
- Cell Biology
Background:
- The juxtaglomerular apparatus (JGA) is vital for regulating blood pressure and ion balance.
- It comprises diverse cells, including smooth muscle cells, endothelial cells, mesangial cells, macula densa cells, and renin-secreting cells.
- Most JGA cells are interconnected by gap junctions, facilitating intercellular communication.
Purpose of the Study:
- To review the role of gap junctions in the juxtaglomerular apparatus.
- To highlight how gap junction-mediated intercellular calcium (Ca2+) signals influence JGA function.
Main Methods:
- Literature review of recent data on JGA gap junctions.
- Analysis of studies investigating intercellular Ca2+ signaling in the JGA.
Main Results:
- Gap junctions enable signal transduction and coordinated multicellular functions within the JGA.
- Disruption of gap junction communication affects preglomerular vascular tone and renin secretion.
- Intercellular Ca2+ signals transmitted through gap junctions are key determinants of JGA physiological responses.
Conclusions:
- Gap junction-mediated communication is essential for JGA homeostasis and blood pressure regulation.
- Understanding these intercellular signals provides insights into JGA physiology and potential therapeutic targets.
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