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Related Concept Videos

Other Disorders of Digestive System01:30

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Published on: December 15, 2011

Coeliac disease.

John S Leeds1, Andrew D Hopper, David S Sanders

  • 1Gastroenterology and Liver Unit, Royal Hallamshire Hospital, Room P39, P Floor, Glossop Road, Sheffield S102JF, UK. john.leeds@sth.nhs.uk

British Medical Bulletin
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

Coeliac disease, an immune-mediated gluten intolerance, affects about 1% of the population. Diagnosis relies on duodenal biopsy, and a gluten-free diet is the primary management, with new therapies and tests on the horizon.

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Area of Science:

  • Gastroenterology
  • Immunology
  • Internal Medicine

Background:

  • Coeliac disease is a prevalent autoimmune disorder caused by gluten intolerance.
  • It often presents with atypical symptoms and remains underdiagnosed.
  • Diagnosis traditionally relies on duodenal biopsy, with a gluten-free diet as the cornerstone of management.

Purpose of the Study:

  • To review recent advancements in coeliac disease diagnosis and management.
  • To summarize current understanding of coeliac disease, including its complications and future research directions.
  • To highlight emerging atypical presentations and novel therapeutic strategies.

Main Methods:

  • Literature review focusing on recent publications in coeliac disease.
  • Emphasis on studies detailing new diagnostic methods and therapies for complications.
  • Primary data source: PubMed and major gastroenterology journals.

Main Results:

  • Coeliac disease prevalence is approximately 1%, with atypical presentations becoming more common.
  • Duodenal biopsy remains the gold standard for diagnosis.
  • A strict gluten-free diet is essential for managing coeliac disease and its complications.

Conclusions:

  • Coeliac disease is a well-understood autoimmune condition, increasingly recognized through atypical presentations.
  • Research is progressing towards alternatives to the gluten-free diet and improved serological screening tests.
  • Further research is timely for refining diagnosis, management, and understanding complications like neurological issues and lymphoma.