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Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Related Experiment Video

Updated: Jun 27, 2026

The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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Tissue specificity and evolution of meristematic WOX3 function.

Rena Shimizu1, Jiabing Ji, Eric Kelsey

  • 1Department of Plant Biology, Cornell University, Ithaca, New York 14853, USA.

Plant Physiology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

The PRESSED FLOWER1 (PRS1) gene in Arabidopsis is crucial for lateral organ development. Its function, alongside WUSCHEL1 (WUS1), highlights conserved stem cell and founder cell development through promoter specificity.

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Published on: November 29, 2016

Area of Science:

  • Plant developmental biology
  • Molecular genetics
  • Arabidopsis thaliana research

Background:

  • The WUSCHEL-related homeobox (WOX) gene PRESSED FLOWER1 (PRS1) is vital for lateral organ formation in Arabidopsis.
  • PRS1 is expressed in the shoot meristem periphery, recruiting founder cells for vegetative and floral organs.
  • Mutations in PRS1 lead to the loss of lateral organs like stipules and sepals.

Purpose of the Study:

  • To investigate the non-cell autonomous function of PRS1 in shoot meristems.
  • To explore the evolutionary divergence of WOX gene functions.
  • To understand the molecular mechanisms underlying lateral organ development.

Main Methods:

  • Utilized meristem layer-specific promoters to analyze PRS1 function.
  • Investigated PRS1 protein localization and trafficking within the shoot meristem.
  • Employed WUSCHEL1 (WUS1) to rescue PRS1 mutant phenotypes under the PRS1 promoter.

Main Results:

  • PRS1 function is not fully rescued by expression solely in L1 or L1-L2 layers, and PRS1 protein does not traffic between layers.
  • PRS1 protein accumulates in all meristem layers (L1-L3) when driven by its native promoter.
  • WUS1 can fully rescue PRS1 mutant phenotypes when driven by the PRS1 promoter, indicating functional overlap.

Conclusions:

  • WUS1 and PRS1 share conserved protein-protein interactions and target gene regulation, suggesting subfunctionalization through promoter divergence.
  • Stem cells and lateral organ founder cells are intrinsically similar, with their fate determined by positional signaling.
  • This study provides insights into the evolution of WOX gene function and plant development.