Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscle Stimulation Frequency01:22

Muscle Stimulation Frequency

The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Electronic Phenotype Series for Measuring Adherence to the Wake Up and Breathe Protocol in Mechanically Ventilated ICU Patients.

Research square·2026
Same author

Auditory Cortex Distinguishes between Spontaneous and Sound-Evoked Movements.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Hierarchical recurrent temporal prediction as a model of the mammalian dorsal visual pathway.

PLoS computational biology·2026
Same author

Intelligent Reasoning Cues: A Framework and Case Study of the Roles of AI Information in Complex Decisions.

Proceedings of the SIGCHI conference on human factors in computing systems. CHI Conference·2026
Same author

Rethinking hierarchy: the auditory system as an integrated cortical-subcortical network.

Nature reviews. Neuroscience·2026
Same author

Executive function and language: a behavioural and functional near-infrared spectroscopy study in 23 normally hearing children and one deaf child with cochlear implants.

Frontiers in human neuroscience·2026

Related Experiment Video

Updated: Jun 27, 2026

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Stimulus-timing-dependent plasticity of cortical frequency representation.

Johannes C Dahmen1, Douglas E H Hartley, Andrew J King

  • 1Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 17, 2008
PubMed
Summary

Spike-timing-dependent plasticity (STDP) shapes auditory cortex responses. Millisecond-scale timing of auditory stimuli induces lasting changes in neuronal frequency selectivity, suggesting STDP is key to auditory system plasticity.

More Related Videos

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Related Experiment Videos

Last Updated: Jun 27, 2026

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
09:42

Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns

Published on: May 12, 2019

Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Synaptic Plasticity

Background:

  • Adult cortical circuits exhibit plasticity influenced by input modification.
  • Spike-timing-dependent plasticity (STDP) is a proposed mechanism for synaptic efficacy changes based on neural activity timing.
  • Previous studies suggest STDP in visual and somatosensory systems.

Purpose of the Study:

  • To investigate the existence and characteristics of STDP in the primary auditory cortex.
  • To determine if auditory stimulus timing can induce plasticity in auditory neurons.
  • To explore the temporal and frequency-specific requirements for auditory plasticity.

Main Methods:

  • Electrophysiological recordings from primary auditory cortex neurons in ferrets (anesthetized and awake).
  • Application of paired pure tone stimuli with precise onset asynchronies (8 or 12 ms).
  • Analysis of shifts in neuronal frequency selectivity following repetitive stimulus pairing.

Main Results:

  • Repetitive pairing of tones induced significant shifts in neuronal frequency selectivity, mimicking STDP.
  • Plasticity was temporally specific, effective only with 8 or 12 ms onset asynchronies.
  • The direction of frequency shifts depended on tone presentation order.
  • Magnitude of shifts was greatest for stimuli < 1 octave apart.
  • Significant plasticity was observed primarily in upper cortical layers.
  • Induced changes persisted for several minutes.

Conclusions:

  • Millisecond-scale timing of sensory input is crucial for shaping neural function in the auditory system.
  • Findings strongly support STDP as a significant mechanism for plasticity in the mature auditory cortex.
  • Auditory cortex plasticity can be induced by precisely timed, repetitive auditory stimuli.