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Related Experiment Video

Updated: Jun 27, 2026

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation
08:04

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation

Published on: August 23, 2017

Walking flexibility after hemispherectomy: split-belt treadmill adaptation and feedback control.

Julia T Choi1, Eileen P G Vining, Darcy S Reisman

  • 1The Kennedy Krieger Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Brain : a Journal of Neurology
|December 17, 2008
PubMed
Summary

Hemispherectomy in children did not affect reactive walking control but impaired some aspects of predictive (feedforward) adaptation, specifically inter-leg timing adjustments. This suggests the cerebrum is crucial for motor timing adaptation during walking.

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Area of Science:

  • Neuroscience
  • Motor Control
  • Human Locomotion

Background:

  • Walking adaptability relies on reactive (feedback) and predictive (feedforward) control mechanisms.
  • Cerebellar damage impairs feedforward adaptation but not feedback control during split-belt treadmill walking.
  • Previous research suggests cerebellar-brainstem pathways are key for feedforward adaptation, with cerebral involvement unclear.

Purpose of the Study:

  • To investigate the role of the cerebrum in walking adaptability after hemispherectomy.
  • To determine if complete removal of a cerebral hemisphere affects feedback and feedforward control during split-belt walking.

Main Methods:

  • Studied split-belt treadmill walking in 10 children/adolescents with hemispherectomy and 10 age/sex-matched controls.
  • Assessed reactive feedback control and feedforward adaptation (inter-leg timing and spatial control).

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Published on: May 16, 2025

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Last Updated: Jun 27, 2026

Using a Split-belt Treadmill to Evaluate Generalization of Human Locomotor Adaptation
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Published on: August 23, 2017

A Rehabilitation Program of Exoskeleton-assisted Body Weight-Supported Treadmill Training with Non-immersive Virtual Reality for Stroke Patients
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Main Results:

  • Hemispherectomy did not impair reactive feedback control.
  • Feedforward adaptation was impaired in some hemispherectomy subjects, specifically in inter-leg timing adaptation.
  • Spatial control adaptation remained intact in hemispherectomy subjects.

Conclusions:

  • The cerebrum plays a role in adapting the timing of limb movements during locomotion.
  • The cerebrum is not essential for reactive feedback control or spatial adaptation during walking.
  • These findings highlight distinct cerebral contributions to different aspects of motor adaptation.