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Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
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Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
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Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
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Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
Gonadal and Placental Hormones01:24

Gonadal and Placental Hormones

The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
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Ex Vivo Placental Explant Flow Culture - Mimicking the Dynamic Conditions In Utero
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The placenta in preterm birth.

O M Faye-Petersen1

  • 1The University of Alabama at Birmingham, Birmingham, AL 35249-7331, USA. onafp@uab.edu

Journal of Clinical Pathology
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Preterm birth, often spontaneous, requires placental evaluation. This review links clinical research on preterm birth causes to placental pathology for pathologists.

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Area of Science:

  • Obstetrics and Gynecology
  • Pathology
  • Perinatal Medicine

Background:

  • Preterm birth rates range from 5-13% in developed nations.
  • Two-thirds of preterm births result from spontaneous preterm labor or preterm premature rupture of membranes.
  • One-third are indicated, following interventions for maternal/fetal conditions like preeclampsia or fetal growth restriction.

Purpose of the Study:

  • To provide pathologists with an overview of recent clinical research in preterm birth pathogenesis.
  • To correlate placental pathologies with major causes of spontaneous preterm birth.
  • To summarize placental findings in indicated preterm births.

Main Methods:

  • Review of recent clinical research on preterm birth pathogenesis.
  • Correlation of clinical findings with placental gross and histopathological features.
  • Synthesis of information for pathological evaluation of preterm placentas.

Main Results:

  • The review links current understanding of preterm birth causes to specific placental pathologies.
  • It highlights the importance of placental examination in determining the etiology of spontaneous preterm birth.
  • Gross and histopathological findings in indicated preterm births are summarized.

Conclusions:

  • Pathologists play a crucial role in evaluating preterm placentas to determine birth causes.
  • Understanding the pathogenesis of preterm birth aids in interpreting placental findings.
  • This review serves as a guide for pathologists assessing placentas from preterm deliveries.