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Theileria apicoplast as a target for chemotherapy
Regina Lizundia1, Dirk Werling, Gordon Langsley
1Département Maladies Infectieuses, Laboratoire de Biologie Cellulaire Comparative des Apicomplexes, UMR 8104 CNRS/U567 INSERM, Hôpital Cochin-Bâtiment Gustave Roussy, Institut Cochin, Paris, France.
Abstract:
Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets. Putative inhibitors of these targets were screened, and we identified antiproliferative compounds that merit further characterization.
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