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Published on: November 9, 2013
Effects of home-based pulmonary rehabilitation in patients with chronic obstructive pulmonary disease: a randomized
François Maltais1, Jean Bourbeau, Stan Shapiro
1Hôpital Laval, Institut Universitaire de Cardiologie et de Pneumologie de l'Université Laval and Centre Hospitalier Universitaire Associé, Québec City, Québec, Canada. francois.maltais@med.ulaval.ca
Background:
Home-based rehabilitation is a promising approach to improve access to pulmonary rehabilitation.
Objective:
To assess whether self-monitored, home-based rehabilitation is as effective as outpatient, hospital-based rehabilitation in patients with chronic obstructive pulmonary disease (COPD).
Design:
Randomized, multicenter, noninferiority trial.
Setting:
10 academic and community medical centers in Canada.
Patients:
252 patients with moderate to severe COPD.
Intervention:
After a 4-week education program, patients took part in home-based rehabilitation or outpatient, hospital-based rehabilitation for 8 weeks. They were followed for 40 weeks to complete the 1-year study.
Measurements:
The primary outcome was the change in Chronic Respiratory Questionnaire dyspnea subscale score at 1 year. The primary analysis took a modified intention-to-treat approach by using all patients who provided data at the specified follow-up time, regardless of their level of adherence. The analysis used regression modeling that adjusted for the effects of center, sex, and baseline level. All differences were computed as home intervention minus outpatient intervention.
Results:
Both interventions produced similar improvements in the Chronic Respiratory Questionnaire dyspnea subscale at 1 year: improvement in dyspnea of 0.62 (95% CI, 0.43 to 0.80) units in the home intervention (n = 107) and 0.46 (CI, 0.28 to 0.64) units in the outpatient intervention (n = 109). The difference between the 2 treatments at 1 year was small and clinically unimportant. The 95% CI of the difference did not exceed the prespecified noninferiority margin of 0.5: difference in dyspnea score of 0.16 (CI, -0.08 to 0.40). Most adverse events were related to COPD exacerbations. No serious adverse event was considered to be related to the study intervention.
Limitation:
The contribution of the educational program to the improvement in health status and exercise tolerance cannot be ascertained.
Conclusion:
Home rehabilitation is a useful, equivalent alternative to outpatient rehabilitation in patients with COPD.
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