[Alterations of tissue blood supply of experimental animals at malignant tumor growth]

The aim of the research was to study tissue blood flow in the dynamics of malignant tumor growth (Ehrlich carcinoma of 80 mice, sarcoma--37-80 rats, 30 rabbit--Brown-Pirs carcinoma) in functionally different organs of experimental animals (mice, rats, rabbits): skeletal muscles, liver, ear, mammary gland and ciliary body of eye. The study was conducted using H clearance method. Deformability of erythrocytes was studied using filtration-photometry method. Blood surface tension was studied by Rebinder bubble maximal pressure method. Obtained data were analyzed by Student's t criterion. The investigation showed that intensity of local hemocirculation and erythrocytes deformability in "intact" organs and tissues of experimental animals in the dynamics of malignant tumor growth progressively decreases while, blood surface tension increases. It was revealed that paraneoplastic disorders of local hemocirculation were stereotyped, universal and common phenomenon for malignant tumor growth. It was concluded that alterations of blood rheology decreased deformability of erythrocytes and increased blood surface tension play one of the leading roles in the mechanism of paraneoplastic disorders of local hemocirculation.