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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

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Related Experiment Videos

Multiple primary choledocholithiasis in sickle cell disease.

Perla Vicari1, Marco Vinicio Fanucchi Gil, Rita de Cássia Rosário Cavalheiro

  • 1Disciplina de Hematologia e Hemoterapia, Universidade Federal de São Paulo, São Paulo, Brazil. perlavicari@hemato.epm.br

Internal Medicine (Tokyo, Japan)
|December 17, 2008
PubMed
Summary

Primary choledocholithiasis is rare in sickle cell disease (SCD). This case highlights an unusual occurrence of multiple bile duct stones and pancreatitis in an SCD patient 14 years post-cholecystectomy.

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Area of Science:

  • Hepatology
  • Gastroenterology
  • Hematology

Background:

  • Choledocholithiasis, or bile duct stones, can be primary or secondary.
  • Sickle cell disease (SCD) patients have a high risk of gallstones due to chronic hemolysis.
  • Primary choledocholithiasis is uncommon in SCD patients.

Observation:

  • A delay in diagnosing biliary tract pathology can occur post-cholecystectomy.
  • Prior cholecystectomy may increase the risk of primary common bile duct stones due to biliary system infection.
  • This report details a severe case of multiple primary choledocholithiasis with pancreatitis in an SCD patient.

Findings:

  • The patient had multiple primary common bile duct stones and pancreatitis.
  • The condition occurred 14 years after a cholecystectomy.
  • This case is unusual due to the rarity of primary choledocholithiasis in SCD patients, especially post-cholecystectomy.

Implications:

  • This case underscores the importance of considering primary choledocholithiasis in SCD patients with biliary symptoms, even after cholecystectomy.
  • It highlights a potential link between prior cholecystectomy and the development of primary bile duct stones in this population.
  • Further research may be warranted to explore the relationship between SCD, cholecystectomy, and primary choledocholithiasis.