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Related Concept Videos

The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...

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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Cell cycle control by the CDC25 phosphatases.

Bernadette Aressy1, Bernard Ducommun

  • 1University of Toulouse, CNRS-UMR5088 and IFR109 "Institut d'Exploration Fonctionnelle des GĂ©nomes", 118 route de Narbonne, 31062 TOULOUSE, France.

Anti-Cancer Agents in Medicinal Chemistry
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Cell division cycle 25 (CDC25) phosphatases regulate cell cycle progression and DNA damage checkpoints. Their dysregulation is linked to cancer, suggesting CDC25 as a therapeutic target.

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Last Updated: Jun 27, 2026

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Cell division cycle 25 (CDC25) phosphatases are crucial for activating cyclin-dependent kinases (CDKs) during the cell cycle.
  • CDC25 phosphatases (CDC25A, CDC25B, CDC25C) are key regulators of the G2/M checkpoint, responding to DNA damage.

Purpose of the Study:

  • To review the regulatory mechanisms of CDC25 phosphatases.
  • To discuss the role of CDC25 in cancer development and progression.
  • To explore therapeutic strategies targeting CDC25 activity in cancer treatment.

Main Methods:

  • Literature review of CDC25 phosphatases.
  • Analysis of CDC25 expression and activity in cancer.
  • Evaluation of CDC25-targeted cancer therapies.

Main Results:

  • CDC25 phosphatases are tightly regulated by various mechanisms, including post-translational modifications and degradation.
  • Altered CDC25 expression contributes to genetic instability and checkpoint bypass.
  • Increased CDC25A and CDC25B expression correlates with poor prognosis in various human cancers.

Conclusions:

  • CDC25 phosphatases are critical for cell cycle control and DNA damage response.
  • Dysregulation of CDC25 is implicated in cancer pathogenesis.
  • Targeting CDC25 activity presents a promising therapeutic strategy for cancer treatment.