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Related Concept Videos

Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
Model Approaches for Pharmacokinetic Data: Compartment Models01:14

Model Approaches for Pharmacokinetic Data: Compartment Models

Compartmental analysis is a widely adopted approach to characterizing drug pharmacokinetics. It uses compartment models that conceptualize the body as a collection of reversibly communicating compartments, each representing a group of tissues exhibiting similar drug distribution characteristics. The movement rate of the drug between these compartments is typically described by first-order kinetics.
Two primary types of compartment models are recognized: mammillary and catenary. The more...
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Drug Control Governance: Regulatory Bodies and Their Impact01:03

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with a...

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Related Experiment Videos

Closing the gap between centralized and decentralized compound management approaches.

Marc R M Andreae1, Thomas Steiner, Matthieu Hueber

  • 1Novartis Institutes for BioMedical Research, Center for Proteomic Chemistry, Basel, Switzerland. marc.andreae@novartis.com

Combinatorial Chemistry & High Throughput Screening
|December 17, 2008
PubMed
Summary

Researchers developed a low-cost, flexible compound storage system for academic labs and pharmaceutical companies. This system, managed by Compound Store Manager software, ensures local access while maintaining global compound accessibility.

Related Experiment Videos

Area of Science:

  • Drug Discovery and Development
  • Chemical Biology
  • Laboratory Management

Background:

  • Growing demand for systematic compound storage in pharmaceutical companies, research organizations, and academic labs.
  • Budget constraints limit smaller institutions' access to expensive commercial storage systems.
  • Need for flexible, cost-effective storage solutions to complement existing automated archives in large organizations.

Purpose of the Study:

  • To present a low-cost, highly flexible compound storage concept for diverse research settings.
  • To address the need for both localized, on-site compound access and global accessibility.
  • To introduce a software solution for managing decentralized storage systems.

Main Methods:

  • Development of a flexible, low-cost manual compound storage system with variable designs.
  • Implementation of Compound Store Manager software for administering multiple global stores.
  • Creation of a backend system with centralized data management for store integration.

Main Results:

  • Successful implementation of a cost-effective and adaptable compound storage solution.
  • Enabled efficient management and integration of decentralized storage facilities.
  • Facilitated quick on-site compound access without compromising global availability.

Conclusions:

  • The developed system offers a viable, budget-friendly alternative for compound storage.
  • Centralized data management and software control enhance the usability of decentralized stores.
  • This approach supports both local needs and global accessibility for chemical compound collections.