Phage display derived therapeutic antibodies

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Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
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Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity

Published on: May 1, 2018

Holger Thie1, Torsten Meyer, Thomas Schirrmann

  • 1Technical University of Braunschweig, Institute of Biochemistry and Biotechnology, Spielmannstr. 7, 38106 Braunschweig, Germany.

Current Pharmaceutical Biotechnology
|December 17, 2008
PubMed

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Hybridoma Technology01:31

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Commonly used fusion techniques — electroporation, polyethylene glycol...