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Construction of Synthetic Phage Displayed Fab Library with Tailored Diversity
Published on: May 1, 2018
Phage display derived therapeutic antibodies
Holger Thie1, Torsten Meyer, Thomas Schirrmann
1Technical University of Braunschweig, Institute of Biochemistry and Biotechnology, Spielmannstr. 7, 38106 Braunschweig, Germany.
Current Pharmaceutical Biotechnology
|December 17, 2008
Summary
Phage display technology has advanced human therapeutic antibody development. This article reviews approved antibodies and 14 detailed examples currently in clinical trials, highlighting progress in antibody engineering.
Area of Science:
- Biotechnology
- Immunology
- Pharmacology
Background:
- Phage display is a key method for discovering and engineering antibodies.
- Therapeutic antibodies have revolutionized disease treatment.
- Significant advancements have been made in antibody-based therapies.
Purpose of the Study:
- To provide an overview of human therapeutic antibody development using phage display.
- To highlight approved therapeutic antibodies and those in clinical trials.
- To detail the characteristics of selected clinical-stage antibodies.
Main Methods:
- Introduction to the phage display technique.
- Review of literature on approved and investigational therapeutic antibodies.
- Detailed case studies of 14 antibodies in clinical trials.
Main Results:
- Phage display has been instrumental in the development of numerous therapeutic antibodies.
- Several antibodies generated via phage display are approved for clinical use.
- A significant number of antibodies are progressing through clinical trials, demonstrating the platform's success.
Conclusions:
- Phage display is a powerful and versatile platform for generating human therapeutic antibodies.
- The ongoing clinical development of antibodies underscores the clinical relevance of phage display.
- Continued innovation in phage display will likely yield further breakthroughs in antibody therapeutics.
