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Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Transducer Mechanism: Enzyme-Linked Receptors01:27

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Related Experiment Video

Updated: Jun 27, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Sirtuin modulators: targets for metabolic diseases and beyond.

B G Szczepankiewicz1, P Y Ng

  • 1Sirtris A GSK Company, 200 Technology Square, Cambridge MA 02139, USA. bszczepankiewicz@sirtrispharma.com

Current Topics in Medicinal Chemistry
|December 17, 2008
PubMed
Summary

Sirtuins are key drug targets for aging-related diseases like diabetes, neurodegeneration, and cancer. This review details chemical activators and inhibitors of sirtuins published by mid-2008.

Related Experiment Videos

Last Updated: Jun 27, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Sirtuins are a class of enzymes crucial for gene regulation across all life forms.
  • Emerging evidence links sirtuin activity to aging processes and age-related diseases.
  • Modulating sirtuin function presents therapeutic potential for conditions including diabetes, cancer, and neurodegenerative disorders.

Purpose of the Study:

  • To review chemical activators and inhibitors of sirtuins.
  • To summarize the literature on sirtuin modulators up to the first half of 2008.

Main Methods:

  • Literature review of chemical sirtuin modulators.
  • Analysis of published data on sirtuin activators and inhibitors.

Main Results:

  • Identification of various chemical agents targeting sirtuins.
  • Distinction between activating and inhibiting compounds for different sirtuin family members.

Conclusions:

  • Sirtuin activators and inhibitors are valuable tools for exploring sirtuin biology.
  • Targeting sirtuins offers promising therapeutic strategies for aging-associated diseases.
  • Further research into sirtuin modulators is warranted for drug development.