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Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

Regulatory T cells as targets for immunotherapy of autoimmunity and inflammation

Wiebke Hansen1, Astrid M Westendorf, Jan Buer

  • 1Immunregulation Group, Institute of Medical Microbiology, University Hospital Essen, Hufelandstrasse 55, Essen, Germany. wiebke.hansen@uk-essen.de

Inflammation & Allergy Drug Targets
|December 17, 2008
PubMed

Regulatory T (Treg) cells are emerging as key players in the regulation of different immune responses, thereby representing potential candidates for therapeutic interventions in a broad variety of immunological disorders. While the reduction or loss in function would be of benefit during the treatment of cancer, induction and/or expansion of Treg cell function might be helpful to interfere with unwanted immune responses in transplantation medicine, during autoimmunity, allergy and inflammation. However, a better understanding of Treg cell biology is a prerequisite to specifically modulate its function during immune responses in vivo. In the present review we will discuss current concepts on different cell types, components and some novel surface receptors expressed by Treg cells, namely Neuropilin-1, CD83 and G protein-coupled receptor 83 which might represent promising targets for the modulation of Treg cell function in human disease.

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