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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Antiasthma Drugs: Leukotriene Modifiers01:19

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Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Should we target allergen protease activity to decrease the burden of allergic airway inflammation?

Harissios Vliagoftis1, Paul Forsythe

  • 1Pulmonary Research Group, University of Alberta, Edmonton, Alberta, Canada. harissios.vliagoftis@ualberta.ca

Inflammation & Allergy Drug Targets
|December 17, 2008
PubMed
Summary

Protease activity is increasingly linked to allergic airway diseases like asthma. Understanding this connection may lead to new treatments for rising allergy and asthma rates.

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Area of Science:

  • Immunology
  • Allergology
  • Biochemistry

Background:

  • Allergy and asthma prevalence is rising globally.
  • Limited new therapeutic options exist for these conditions.
  • Proteases are implicated in allergic sensitization and airway inflammation.

Purpose of the Study:

  • To review the evidence linking protease activity to allergic airway disease.
  • To suggest future research directions in this field.

Main Methods:

  • Literature review of studies on proteases, allergens, and allergic airway disease.
  • Analysis of the relationship between allergen protease activity and disease induction.

Main Results:

  • Most major allergens possess protease activity.
  • This activity is closely correlated with their ability to induce sensitization and inflammation.
  • Proteases play a significant role in allergic airway inflammation.

Conclusions:

  • Protease activity is a key factor in the development and exacerbation of allergic airway diseases.
  • Targeting protease activity presents a potential therapeutic strategy for allergy and asthma.