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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

Teeth

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The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
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Oral Drug Delivery Systems: Continuous-Release Systems

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

Modified-Release Drug Delivery Systems: Rate-Programmed I

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Related Experiment Video

Updated: Jun 27, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Dental therapeutic systems.

Zeenat Iqbal¹, Nilu Jain, Gaurav K Jain

¹Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

Recent Patents on Drug Delivery & Formulation

|December 17, 2008

Summary

Local delivery of antibacterials offers a new approach to treating periodontal disease, overcoming antibiotic resistance and systemic side effects. Recent innovations focus on controlled release systems for effective periodontal pocket treatment.

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Last Updated: Jun 27, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

Periodontology
Drug Delivery Systems
Biomaterials Science

Background:

Periodontal diseases are increasingly treated with local antibiotherapy due to antimicrobial resistance and adverse effects of systemic antibiotics.
Local delivery systems provide targeted treatment within the periodontal pocket, minimizing systemic exposure.
Significant advancements have been made in local drug delivery for periodontal conditions since 1989.

Purpose of the Study:

To review recent advancements in local drug delivery systems for periodontal disease treatment.
To highlight innovative approaches and patented technologies in this field.

Main Methods:

Review of scientific literature and patents related to local periodontal drug delivery.
Analysis of various formulations including polymers, biodegradable materials, and micro/nanoparticles.
Examination of delivery devices such as strips, fibers, gels, ointments, and injectables.

Main Results:

Various local delivery systems are being developed, including polymer-based, collagen-based, and cellulose acetate fiber systems.
Multiparticulate systems, bio-absorbable materials, gels, ointments, injectables, microcapsules, and nanospheres are suitable for direct periodontal pocket placement.
Lozenges, buccoadhesive tablets, discs, and gels can effectively reduce gingival inflammation.
Controlled local delivery maintains therapeutic concentrations in gingival crevicular fluid, avoiding systemic side effects.
Numerous patents demonstrate ongoing innovation in controlled-release systems for oral care and periodontitis treatment.

Conclusions:

Local delivery systems offer a promising strategy for managing periodontal diseases by providing targeted, sustained release of therapeutic agents.
Ongoing research and patent filings indicate a dynamic field focused on improving treatment efficacy and patient safety.