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Recent patents relating to tumor suppressor genes
1McDonnell Boehnen Hulbert & Berghoff LLP, Suite 3100, 300 S. Wacker Drive, Chicago, IL 60606, USA. derry@mbhb.com
Recent Patents on DNA & Gene Sequences
|December 17, 2008
Summary
Recent patents reveal novel tumor suppressor genes like WWOX and CAR-1, alongside new applications for known genes such as CASP8 and WT1, advancing cancer treatment and diagnostics.
Area of Science:
- Oncology and Genetics
- Molecular Biology
- Biotechnology
Background:
- Tumor suppressor genes are critical targets for cancer diagnosis and treatment.
- Ongoing research focuses on identifying and characterizing these genes.
- Recent patent literature highlights significant advancements in this field.
Purpose of the Study:
- To review recent patents and patent applications related to tumor suppressor genes.
- To highlight newly discovered and characterized tumor suppressor genes.
- To showcase innovative applications of tumor suppressor genes in cancer research.
Main Methods:
- Analysis of recent patent and patent application disclosures.
- Identification of specific tumor suppressor genes mentioned, including WWOX, CAR-1, HCCS-1, SSeCKS, ARTS1, and DOS.
- Review of patents detailing novel roles for known genes (CASP8, WT1) and gene constructs.
Main Results:
- Discovery of novel tumor suppressor genes: WW Domain-Containing Oxidoreductase (WWOX), Cancer Associated Ring-1 (CAR-1), Human Cervical Cancer Suppressor 1 (HCCS-1), Src-suppressed C kinase substrate (SSeCKS), ADP-Ribosylation factor-like putative Tumor Suppressor gene 1 (ARTS1), and Deleted in Osteosarcoma (DOS).
- Identification of Caspase-8 (CASP8) as a tumor suppressor.
- Development of Wilms Tumor suppressor gene (WT1) peptides for cancer vaccines and a p51 gene fragment for compound screening.
Conclusions:
- Recent patents offer valuable insights into newly identified and characterized tumor suppressor genes.
- Innovative applications, including cancer vaccines and therapeutic agents, are emerging from this research.
- These advancements hold significant promise for the future of cancer treatment and diagnosis.
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