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Recent patents relating to tumor suppressor genes
1McDonnell Boehnen Hulbert & Berghoff LLP, Suite 3100, 300 S. Wacker Drive, Chicago, IL 60606, USA. derry@mbhb.com
Abstract:
Researchers in the field of tumor suppressor genes are actively attempting to discover new tumor suppressor genes and/or characterize known tumor suppressor genes with the intention of treating and diagnosing cancers. A number of recent patents and patent applications have been published that discuss some of these discoveries. Some of the patents and patent applications discuss newly discovered tumor suppressor genes, including WW Domain-Containing Oxidoreductase (WWOX), Cancer Associated Ring-1 (CAR-1), Human Cervical Cancer Suppressor 1 (HCCS-1), Src-suppressed C kinase substrate (SSeCKS), ADP-Ribosylation factor-like putative Tumor Suppressor gene 1 (ARTS1), and Deleted in Osteosarcoma (DOS). One recent patent describes the discovery that known caspase family member caspase-8 (CASP8) is a tumor suppressor. Another recent patent describes the use of Wilms Tumor suppressor gene (WT1) peptides as a cancer vaccine. In addition, Sakai et al. received a patent describing a fragment of the p51 tumor suppressor gene containing a promoter region, which is useful for identifying compounds that modulate p51 activity. Another patent application recently published describes a chimeric tumor suppressor gene generated by combining a portion of the rat PEG-3 protein with the human GADD34 protein, thus creating a protein with apoptotic activity. These patents and patent applications provide valuable information that may be useful in fighting cancer by focusing on tumor suppressor gene activities.
Insights
Recent patents reveal novel tumor suppressor genes like WWOX and CAR-1, alongside new applications for known genes such as CASP8 and WT1, advancing cancer treatment and diagnostics.
Area of Science:
- Oncology and Genetics
- Molecular Biology
- Biotechnology
Background:
- Tumor suppressor genes are critical targets for cancer diagnosis and treatment.
- Ongoing research focuses on identifying and characterizing these genes.
- Recent patent literature highlights significant advancements in this field.
Purpose of the Study:
- To review recent patents and patent applications related to tumor suppressor genes.
- To highlight newly discovered and characterized tumor suppressor genes.
- To showcase innovative applications of tumor suppressor genes in cancer research.
Main Methods:
- Analysis of recent patent and patent application disclosures.
- Identification of specific tumor suppressor genes mentioned, including WWOX, CAR-1, HCCS-1, SSeCKS, ARTS1, and DOS.
- Review of patents detailing novel roles for known genes (CASP8, WT1) and gene constructs.
Main Results:
- Discovery of novel tumor suppressor genes: WW Domain-Containing Oxidoreductase (WWOX), Cancer Associated Ring-1 (CAR-1), Human Cervical Cancer Suppressor 1 (HCCS-1), Src-suppressed C kinase substrate (SSeCKS), ADP-Ribosylation factor-like putative Tumor Suppressor gene 1 (ARTS1), and Deleted in Osteosarcoma (DOS).
- Identification of Caspase-8 (CASP8) as a tumor suppressor.
- Development of Wilms Tumor suppressor gene (WT1) peptides for cancer vaccines and a p51 gene fragment for compound screening.
Conclusions:
- Recent patents offer valuable insights into newly identified and characterized tumor suppressor genes.
- Innovative applications, including cancer vaccines and therapeutic agents, are emerging from this research.
- These advancements hold significant promise for the future of cancer treatment and diagnosis.
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