Related Experiment Video

Updated: Jun 27, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

Recent patents on the identification and clinical application of microRNAs and target genes

Min Wang1, Hehuang Xie, Shuangli Mi

  • 1Children's Memorial Research Center, Chicago, Illinois 60614, USA. mwang@childrensmemorial.org

Recent Patents on DNA & Gene Sequences
|December 17, 2008
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are crucial in cell processes. Dysregulation of miRNA networks is linked to cancer, driving research in miRNA prediction, identification, and therapeutic applications.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression by targeting messenger RNAs (mRNAs).
  • They play vital roles in cellular processes like proliferation, differentiation, and apoptosis.
  • Disruption of miRNA-mediated gene regulatory networks is implicated in diseases, particularly cancer.

Purpose of the Study:

  • To review recent advancements in computational and experimental methods for miRNA and target identification.
  • To summarize patent landscape and research progress in miRNA-based cancer diagnosis and therapy.

Main Methods:

  • Review of recent patents and scientific literature.
  • Focus on computational prediction algorithms and experimental validation techniques for miRNA-target interactions.
  • Exploration of miRNA roles in cancer biology.

Main Results:

  • miRNAs are key regulators of gene expression with broad biological impact.
  • Computational and experimental methods for miRNA and target identification are rapidly evolving.
  • Significant potential exists for miRNA-based diagnostics and therapeutics in oncology.

Conclusions:

  • miRNA research is a rapidly expanding field with growing patent activity.
  • Accurate identification of miRNAs and their targets is essential for understanding their roles in disease.
  • miRNAs hold promise for novel cancer treatment strategies and diagnostic tools.

More Related Videos

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells07:19

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

Published on: September 28, 2011

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs11:00

Biotin-based Pulldown Assay to Validate mRNA Targets of Cellular miRNAs

Published on: June 12, 2018

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...