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Updated: Jun 27, 2026
09:51
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
Published on: July 26, 2017
Recent developments in patents targetingToll-like receptor genes
Mohini Saini1, Dhanjit K Das, Animesh Dhara
1Centre for Wildlife Conservation Management and Disease Surveillance, Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India. mohini@ivri.up.nic.in
Recent Patents on DNA & Gene Sequences
|December 17, 2008
Summary
Toll-like receptors (TLRs) are key to innate immunity, sensing pathogens and orchestrating adaptive responses. Research explores using TLR agonists to modulate immunity against infections and reviews genetic variations linked to diseases.
Area of Science:
- Immunology
- Genetics
Background:
- Toll-like receptors (TLRs) are pattern recognition receptors crucial for innate host defense.
- They are conserved across species and expressed on various immune and non-immune cells.
- Thirteen TLRs in mammals recognize a diverse array of pathogens.
Purpose of the Study:
- To review the modulation of mammalian innate immunity using TLR agonists for combating infections.
- To examine the association of single nucleotide polymorphisms (SNPs) in TLR genes with infectious and inherited diseases.
Main Methods:
- Literature review of recent research on TLR agonists and innate immunity modulation.
- Review of studies investigating the link between TLR gene SNPs and human diseases.
Main Results:
- TLR agonists show potential in modulating innate immunity to fight infections.
- Specific TLR gene SNPs are associated with the incidence and progression of various human diseases.
Conclusions:
- TLRs are central to host defense, offering therapeutic targets.
- Understanding TLRs and their genetic variations is vital for disease management and treatment.
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