Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunological abnormalities in pediatric AIDS.

T Español1, X Garcia, I Caragol

  • 1Pediatric Hospital R.S. Valle Hebron, Barcelona, Spain.

Immunological Investigations
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A multicentre evaluation of the Elecsys<sup>®</sup> HIV Duo assay.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2019
Same author

Serum hepatitis B core-related antigen is more accurate than hepatitis B surface antigen to identify inactive carriers, regardless of hepatitis B virus genotype.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2017
Same author

[Pulmonary co-infection due to Nocardia cyriacigeorgica and Aspergillus fumigatus].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia·2017
Same author

Quality Assessment of Postmortem Tissue Donors in a University Hospital: Detection and Generation Tissue Indicators.

Transplantation proceedings·2016
Same author

Placing ecosystem services at the heart of urban water systems management.

The Science of the total environment·2016
Same author

Experience with Guillain-Barré syndrome in a neurological Intensive Care Unit.

Neurologia (Barcelona, Spain)·2014
Same journal

Immune Reconstitution After Hematopoietic Stem Cell Transplantation: Cellular Dynamics, Clinical Determinants, and Emerging Therapeutic Strategies.

Immunological investigations·2026
Same journal

Riboflavin Modulates Complement Activation, Immune Cell Viability and Activation, and Neutrophil Microbicidal Functions <i>in Vitro</i>.

Immunological investigations·2026
Same journal

Pharmacological Modulation of Immunosenescence and Inflammaging: Senolytics, Senomorphics, and Emerging Therapies.

Immunological investigations·2026
Same journal

Nanoantibodies: A Review of Diagnostic and Therapeutic Applications in Respiratory Diseases.

Immunological investigations·2026
Same journal

TRIM31: A Novel Guardian Against Periodontal Inflammation via Modulation of NLRP3 Inflammasome and Macrophage Polarization.

Immunological investigations·2026
Same journal

LincRNA-Cox2 in Inflammation: Regulatory Networks, Experimental Insights, and Future Directions.

Immunological investigations·2026
See all related articles

Perinatal HIV infection severely impacts infant immune systems, causing early abnormalities. Immunoglobulin therapy can improve outcomes by managing bacterial infections and viral replication.

Area of Science:

  • Immunology
  • Pediatrics
  • Infectious Diseases

Background:

  • Vertical transmission of Human Immunodeficiency Virus (HIV) profoundly affects fetal and infant immune development.
  • HIV infection during the perinatal period can lead to precocious immunological abnormalities and clinical manifestations between 2-5 years of age.

Purpose of the Study:

  • To describe the immunological implications of fetal HIV infection.
  • To distinguish patterns of HIV infection in infants.
  • To evaluate the efficacy of immunoglobulin substitution therapy.

Main Methods:

  • Observational study of infants born to HIV-infected mothers.
  • Clinical and immunological assessment of affected children.
  • Analysis of disease progression and response to treatment.

Related Experiment Videos

Main Results:

  • HIV infection severely compromises the developing fetal immune system.
  • Two distinct patterns of HIV infection are observed in infants.
  • Humoral immunodeficiency is common, leading to recurrent bacterial infections and disease progression.
  • Immunoglobulin substitution therapy demonstrated clinical improvement and reduced viral replication.

Conclusions:

  • Perinatal HIV infection causes significant and early immune system damage.
  • Management strategies should address humoral immunodeficiency and its consequences.
  • Immunoglobulin therapy is a valuable intervention for improving clinical outcomes in pediatric HIV infection.