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Updated: Jun 27, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Neurocognitive functions in euthymic bipolar patients.

K Jamrozinski¹, O Gruber, C Kemmer

¹Department of Psychiatry and Psychotherapy, Georg-August-University Goettingen, Goettingen, Germany.

Acta Psychiatrica Scandinavica

|December 17, 2008

Summary

This summary is machine-generated.

Antipsychotic medications may impair cognitive functions in euthymic bipolar I disorder patients, affecting memory and executive functions. Further research is needed to clarify these medication side effects on neuropsychological test performance.

Related Experiment Videos

Last Updated: Jun 27, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Area of Science:

Neuroscience
Psychiatry

Background:

Bipolar disorder is associated with neurocognitive deficits.
Previous meta-analyses suggest impairments in attention, processing speed, memory, and executive functions.

Purpose of the Study:

To assess neurocognitive impairment in euthymic bipolar I disorder patients compared to healthy controls.
To investigate the impact of medication side-effects and illness characteristics on neuropsychological test performance.

Main Methods:

A cross-sectional study compared 40 euthymic bipolar I disorder patients with 40 healthy controls.
Neuropsychological tests assessed IQ, psychomotor speed, verbal fluency, memory, executive functions, and attention.

Main Results:

Patients not using antipsychotics showed no significant cognitive differences compared to controls.
Patients on antipsychotics exhibited significant underperformance in semantic fluency, verbal learning, recognition memory, and planning abilities.
These deficits persisted even after controlling for clinical features.

Conclusions:

Antipsychotic medication significantly impacts cognitive functions in euthymic bipolar patients.
Consideration of antipsychotic use is crucial when interpreting neuropsychological test results in this population.