Related Experiment Video
Updated: Aug 19, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Comparative effects of an elemental and a complex enteral feeding formulation on the absorption of phenytoin
1Department of Medicine, Mary Imogene Bassett Hospital, Cooperstown, New York 13326.
Abstract:
The effect of an elemental formula (Vivonex TEN) and a lactose-free complex formula (Ensure) on the oral absorption of a single dose of phenytoin suspension was determined in 10 normal volunteers. Following an overnight fast, subjects were randomly administered 400 mg of phenytoin suspension alone, phenytoin plus Vivonex TEN (unflavored), and phenytoin plus Ensure. The enteral feedings were given every 4 hours throughout the first 24 hours. Serum phenytoin concentrations were obtained over the 72-hour period following drug administration. No statistical difference in area under the curve (AUC), time to peak phenytoin concentration, or peak phenytoin concentration was observed during the three treatment phases. These data suggest that the two enteral feeding formulations investigated do not interfere with nor enhance or accelerate phenytoin absorption as determined by a single-dose study.
More Related Videos
08:59An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
Related Concept Videos
Factors Influencing Drug Absorption: Physicochemical Parameters
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Factors Influencing Drug Absorption: Drug Dissolution
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Distribution