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Related Experiment Video

Updated: Jun 27, 2026

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Cutaneous expression of systemic candidiasis.

J Pedraz¹, Y Delgado-Jiménez, S Pérez-Gala

¹Departments of Dermatology and Pathology, Hospital Universitario de la Princesa, Madrid, Spain. javierpedraz@mixmail.com

Clinical and Experimental Dermatology

|December 17, 2008

Summary

This summary is machine-generated.

Cutaneous manifestations in immunocompromised patients can signal invasive Candida infections. Early recognition of these skin lesions aids in rapid diagnosis and treatment of systemic candidiasis.

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Area of Science:

Dermatology
Infectious Diseases
Mycology

Background:

Systemic candidiasis (SC) diagnosis is often delayed due to non-specific symptoms and unreliable blood cultures.
Cutaneous manifestations are infrequent in SC but can provide crucial diagnostic clues.

Observation:

Three immunocompromised patients with SC presented with maculopapular or nodular skin lesions.
Lesions appeared on the trunk and extremities, initially asymptomatic or mildly pruritic, accompanied by high fever.

Findings:

Candida species were isolated from blood cultures in all cases; yeast was confirmed histologically in two.
Most skin lesions resolved following antifungal therapy, indicating a response to treatment.

Implications:

Recognizing characteristic skin lesions can expedite SC diagnosis in immunocompromised individuals.
Antifungal treatment, including fluconazole or amphotericin B, is essential for managing SC with cutaneous involvement.
Further research is needed to optimize diagnostic strategies and treatment protocols for SC.