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Updated: Jun 27, 2026

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Published on: August 20, 2019
Variation in the dysbindin gene and normal cognitive function in three independent population samples
M Luciano1, F Miyajima, P A Lind
1Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK. michelle.luciano@ed.ac.uk
The dysbindin gene (DTNBP1) is linked to cognitive functions like memory and executive function. Genetic variations in DTNBP1 consistently associate with cognitive abilities across diverse populations.
Area of Science:
- Neurogenetics
- Cognitive Neuroscience
Background:
- The dysbindin gene (DTNBP1) has been implicated in cognitive processes.
- Previous studies suggest associations between DTNBP1 and cognitive abilities, but specific functional variants and affected cognitive domains require further elucidation.
Purpose of the Study:
- To investigate the association between DTNBP1 genotype and various cognitive abilities.
- To examine these associations across three independent population samples.
Main Methods:
- Genotyping of single nucleotide polymorphisms (SNPs) and haplotypes within the DTNBP1 gene.
- Cognitive assessments including measures of memory, executive function, verbal ability, and general cognitive ability.
- Statistical analysis of genotype-phenotype correlations across Scottish, Australian, and English cohorts.
Main Results:
- Significant associations (P < 0.05) were observed between DTNBP1 SNPs/haplotypes and cognitive measures in all cohorts.
- Specific SNPs (rs2619528, rs1011313, rs1018381, rs2619522) showed consistent associations with executive function, verbal ability, and memory/speed across cohorts.
- A novel SNP (rs742105) demonstrated strong association with memory measures in the English cohort.
- Evidence for association with general cognitive ability was equivocal.
Conclusions:
- The findings support the involvement of the dysbindin gene (DTNBP1) in cognitive function.
- Further research is necessary to identify the precise functional variants and the specific cognitive abilities they influence.
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