Related Experiment Video
Updated: Jun 27, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
The use of hypertonic saline for fluid resuscitation in sepsis: a review
Anil Singh1, Brian W Carlin, Daniel Shade
1Division of Pulmonary and Critical Care Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, USA.
Abstract:
Early volume resuscitation of a patient with sepsis has been shown to reduce morbidity, mortality, and healthcare resource consumption. Hypertonic saline offers a theoretically viable option for volume resuscitation. This article reviews the current information available regarding fluid resuscitation in patients with sepsis, with emphasis on the use of hypertonic saline.
Related Concept Videos
Acute Kidney Injury VI: Nursing Management
Tonicity in Animals
Ascites
Acute Kidney Injury V: Interprofessional Care
Heart Failure VI: Adjunct Therapies
Heart Failure Drugs: Diuretics

