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A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

Islets isolated from donors with elevated HbA1c can be successfully transplanted.

Angela Koh¹, Tatsuya Kin, Sharleen Imes

¹Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada.

Transplantation

|December 17, 2008

Summary

Pancreases from donors with mild hyperglycemia can yield sufficient islets for transplantation. These islets, even with altered cell proportions, can improve glycemic control in type 1 diabetes patients.

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Last Updated: Jun 27, 2026

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Area of Science:

Endocrinology
Transplantation Immunology
Metabolic Diseases

Background:

Clinical islet transplantation is a promising therapy for type 1 diabetes but faces donor organ scarcity.
Donor selection criteria often exclude individuals with mild hyperglycemia, potentially limiting the islet supply.

Observation:

Two cases of islet isolation from donors with elevated hemoglobin A1c (HbA1c) levels (6.3% and 7.9%) are presented.
Adequate islet isolation yields were achieved, yielding 521,350 and 497,472 islet equivalents.
Graft analysis of the higher HbA1c donor showed a reduced beta-cell proportion (21.6%) and increased alpha-cell proportion (51.0%).

Findings:

Both islet preparations were successfully transplanted into recipients with brittle type 1 diabetes.
One recipient achieved insulin independence for 4 years with good glycemic control.
The other recipient, receiving islets from the higher HbA1c donor, experienced a 56% reduction in insulin requirements.

Implications:

Pancreases from donors with mild hyperglycemia represent a potential, previously underutilized source for islet isolation.
This expands the donor pool for clinical islet transplantation, offering hope for more type 1 diabetes patients.
Further research into the long-term function and characteristics of islets from hyperglycemic donors is warranted.