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Related Experiment Video

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Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

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More Aggressive Drug Treatment of Rheumatoid Arthritis in a University-based Practice.

C M Wise¹, J Bruzzese, W N Roberts

¹Division of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Medical College of Virginia.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases

|December 17, 2008

Summary

Rheumatoid arthritis treatment became more aggressive between 1987 and 1993. Physicians increased corticosteroid and methotrexate use while decreasing nonsteroidal anti-inflammatory drugs for rheumatoid arthritis patients.

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Area of Science:

Rheumatology
Clinical Pharmacology

Background:

Treatment guidelines for rheumatoid arthritis (RA) evolve based on new research and recommendations.
Assessing changes in clinical practice is crucial for understanding treatment evolution.

Purpose of the Study:

To evaluate the impact of recent observations and recommendations on RA treatment.
To compare RA drug regimens over a six-year period (1987-1993) in a university rheumatology practice.

Main Methods:

Retrospective analysis of patient data from outpatient rheumatology clinics.
Comparison of treatment regimens for rheumatoid arthritis patients in 1987 and 1993.
Ensuring population similarity in age, race, sex, disease duration, and seropositivity.

Main Results:

Nonsteroidal anti-inflammatory drug (NSAID) use decreased from 85% to 74%.
Corticosteroid use increased from 31% to 44%.
Second-line agent use rose from 46% to 65%, primarily driven by increased methotrexate use (11% to 32%).

Conclusions:

Rheumatoid arthritis drug therapy intensified between 1987 and 1993.
Increased utilization of corticosteroids and methotrexate reflects a more aggressive treatment approach.
Physicians shifted away from NSAIDs towards more potent disease-modifying agents.