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Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights

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Churg-strauss syndrome with diffuse gastrointestinal involvement.

M Berarducci¹, C Thomas, J Kay

¹Departments of Medicine (M.B., J.K.) and Pathology (C.T.), Lahey Hitchcock Medical Center, Burlington, Massachusetts and Harvard Medical School (J.K.), Boston, Massachusetts.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases

|December 17, 2008

Summary

Churg-Strauss syndrome (CSS) can cause severe gastrointestinal (GI) issues, including perforation. Prompt surgical intervention and immunosuppressive therapy, like cyclophosphamide, are crucial for managing GI vasculitis in CSS patients.

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Chronic Salmonella Infection Induced Intestinal Fibrosis

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

Gastroenterology
Rheumatology
Immunology

Background:

Churg-Strauss syndrome (CSS), also known as eosinophilic granulomatosis with polyangiitis, is a rare systemic vasculitis.
Gastrointestinal (GI) involvement in CSS is uncommon but can lead to severe complications.

Purpose of the Study:

To report a unique case of diffuse GI involvement in CSS.
To highlight the diagnostic challenges and management strategies for GI vasculitis in CSS.

Main Methods:

Case report of a 37-year-old male with CSS.
Documentation of jejunal perforation, sigmoid colon inflammation, and gastric ulcer.
Review of diagnostic modalities including endoscopy and angiography.
Assessment of treatment response to corticosteroids and cyclophosphamide.

Main Results:

The patient presented with diffuse GI vasculitis, leading to jejunal perforation and peritonitis.
Endoscopic biopsy and abdominal angiography were inconclusive for diagnosing GI vasculitis.
Surgical intervention was required for the perforation.
Combination therapy with corticosteroids and cyclophosphamide led to resolution.

Conclusions:

Diffuse GI involvement in CSS can manifest with life-threatening complications like ischemia and perforation.
Diagnostic tools like endoscopy and angiography may have limited sensitivity for GI vasculitis in CSS.
Early surgical intervention and intensified immunosuppression (corticosteroids plus cyclophosphamide) are vital for improving outcomes in CSS-related GI vasculitis.