Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-risk osteoporosis clinic (HiROC): improving osteoporosis and postfracture care with an organized, programmatic approach.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2014
Same author

The Use of Low-dose Oral Methotrexate in the Treatment of Polymyositis and Dermatomyositis.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

The arthritis of primary biliary cirrhosis: clinical features and associated immune processes.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2008
Same author

Improving detection and treatment of osteoporosis: redesigning care using the electronic medical record and shared medical appointments.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2008
Same author

Redesigning the care of rheumatic diseases at the practice and system levels. Part 1: practice level process improvement (Redesign 101).

Clinical and experimental rheumatology·2007
Same author

Redesigning the care of rheumatic diseases at the practice and system levels. Part 2: system level process improvement (Redesign 201).

Clinical and experimental rheumatology·2007
Same journal

Risk of Femoral Head Osteonecrosis Following Hip Trauma in Adults With Systemic Lupus Erythematosus.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
Same journal

Efficacy and Safety of Intravenous Golimumab in Patients With Ankylosing Spondylitis and Complete Spinal Ankylosis: Results Through Week 52 of the GO-ALIVE Study: Erratum.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
Same journal

Efficacy and Safety of Intravenous Golimumab in Ankylosing Spondylitis Patients With Early and Late Disease Through One Year of the GO-ALIVE Study: Erratum.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
Same journal

Microbiome Dysbiosis as a Potential Driver of Inflammatory Mimicry in Pachydermoperiostosis-associated Hypertrophic Osteoarthropathy.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
Same journal

Understanding Gaps in Methotrexate Education in the Adolescent and Young Adult Population.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
Same journal

Prevalence of Attention Deficit Hyperactivity Disorder in Adult Patients With Fibromyalgia.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Preparation and Respirometric Assessment of Mitochondria Isolated from Skeletal Muscle Tissue Obtained by Percutaneous Needle Biopsy
11:27

Preparation and Respirometric Assessment of Mitochondria Isolated from Skeletal Muscle Tissue Obtained by Percutaneous Needle Biopsy

Published on: February 7, 2015

Needle muscle biopsy.

E D Newman1, A D Garbes

  • 1Department of Rheumatology (E.D.N.) and Laboratory Medicine (A.D.G.), Geisinger Medical Center, Danville, Pennsylvania.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|December 17, 2008
PubMed
Summary
This summary is machine-generated.

Needle muscle biopsy is a safe and cost-effective alternative to open biopsy for diagnosing myopathies. This outpatient procedure shows minimal complications and influences therapeutic decisions, especially for idiopathic inflammatory myopathies.

More Related Videos

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
07:16

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

Published on: March 4, 2016

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation
05:18

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation

Published on: September 27, 2020

Related Experiment Videos

Last Updated: Jun 27, 2026

Preparation and Respirometric Assessment of Mitochondria Isolated from Skeletal Muscle Tissue Obtained by Percutaneous Needle Biopsy
11:27

Preparation and Respirometric Assessment of Mitochondria Isolated from Skeletal Muscle Tissue Obtained by Percutaneous Needle Biopsy

Published on: February 7, 2015

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
07:16

Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome

Published on: March 4, 2016

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation
05:18

Collection of Skeletal Muscle Biopsies from the Superior Compartment of Human Musculus Tibialis Anterior for Mechanical Evaluation

Published on: September 27, 2020

Area of Science:

  • Neurology
  • Pathology
  • Musculoskeletal Diseases

Background:

  • Muscle biopsy is crucial for diagnosing various myopathies.
  • Open muscle biopsy can be invasive and costly.

Purpose of the Study:

  • To review the experience with needle muscle biopsy for diagnosing myopathies.
  • To evaluate the safety, efficacy, and cost-effectiveness of needle muscle biopsy compared to open biopsy.

Main Methods:

  • Retrospective review of 40 consecutive needle muscle biopsies of the quadriceps muscle.
  • Procedures performed by a single operator, primarily in an outpatient setting.
  • Pathological interpretation and clinical follow-up via chart review.

Main Results:

  • Needle muscle biopsy diagnosed idiopathic inflammatory myopathies in 13 of 27 suspected patients.
  • Other diagnoses included mitochondrial myopathy, neuropathy, and fiber atrophy.
  • No significant complications were observed; procedure was well-tolerated.
  • Therapeutic decisions were significantly influenced by biopsy results in suspected idiopathic inflammatory myopathy cases.
  • Needle biopsy costs were approximately 40% lower than open biopsies.

Conclusions:

  • Needle muscle biopsy is a safe, effective, and cost-effective alternative to open biopsy for evaluating myopathies.
  • It is particularly valuable in diagnosing idiopathic inflammatory myopathies and guiding treatment.
  • The outpatient approach minimizes complications and healthcare costs.