Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Compact Bone

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...

The Bone Matrix

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...

Bone as Supporting Connective Tissue

Bone as Supporting Connective Tissue

Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts— that give the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Enhanced prediction of fracture risk combining vertebral fracture status and BMD.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2007

Same author

Cigarette smoking and the risk for cartilage loss and knee pain in men with knee osteoarthritis.

Annals of the rheumatic diseases·2006

Same author

Severity of vertebral fracture reflects deterioration of bone microarchitecture.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2006

Same author

Comparison of BMD precision for Prodigy and Delphi spine and femur scans.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2006

Same author

Responsiveness, effect size, and smallest detectable difference of Magnetic Resonance Imaging in knee osteoarthritis.

Osteoarthritis and cartilage·2006

Same author

Effect of spinal degenerative changes on volumetric bone mineral density of the central skeleton as measured by quantitative computed tomography.

Acta radiologica (Stockholm, Sweden : 1987)·2005

Same journal

Understanding Gaps in Methotrexate Education in the Adolescent and Young Adult Population.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Same journal

Prevalence of Attention Deficit Hyperactivity Disorder in Adult Patients With Fibromyalgia.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Same journal

Physical, Psychological, Social Support, Adherence, and Educational Factors Associated With Self-Efficacy in Rheumatoid Arthritis: Scoping Review.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Same journal

Pulmonary Hypertension in Systemic Lupus Erythematosus Among Black and Hispanic Patients: An Observational Cohort Study.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Same journal

Linear Gingival Erythema Presenting in Systemic Lupus Erythematous.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

Same journal

Pericardial Involvement in Systemic Lupus Erythematosus.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Interpretation of bone densitometry.

¹Department of Radiology, University of California, San Francisco, California.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases

|December 17, 2008

Summary

This summary is machine-generated.

Noninvasive skeletal assessment methods, including bone densitometry, are advancing for early osteoporosis detection, monitoring, and fracture risk assessment. This review covers current capabilities and appropriate use criteria for these important diagnostic tools.

More Related Videos

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Related Experiment Videos

Last Updated: Jun 27, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Area of Science:

Medical Imaging
Orthopedics
Radiology

Background:

Osteoporosis diagnosis and management rely on accurate skeletal assessment.
Noninvasive methods are crucial for early detection and monitoring disease progression.
Fracture risk prediction is essential for patient management and preventative strategies.

Purpose of the Study:

To review current bone densitometry methods for skeletal assessment.
To highlight recent technical advancements in bone densitometry.
To define appropriate use criteria for bone densitometry.

Main Methods:

Review of existing literature on bone densitometry techniques.
Analysis of technical innovations in skeletal assessment.
Evaluation of clinical guidelines for bone densitometry application.

Main Results:

Significant progress in noninvasive skeletal assessment methods.
Bone densitometry capabilities have advanced considerably.
Established criteria for appropriate use of bone densitometry exist.

Conclusions:

Noninvasive skeletal assessment is vital for early osteoporosis detection.
Bone densitometry plays a key role in monitoring treatment response.
Accurate fracture risk assessment is achievable with current methods.