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Updated: Jun 27, 2026
10:01
Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Is there cyclosporine-induced bone disease?
1Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Summary
Cyclosporine may negatively impact bone health by increasing bone resorption, a concern supported by animal and human studies. Current research indicates no specific counter-agent, highlighting the need for general bone health strategies.
Area of Science:
- Immunopharmacology
- Bone Biology
- Nephrology
Background:
- Cyclosporine is an immunosuppressive drug with known systemic effects.
- Its impact on bone metabolism remains controversial, with conflicting evidence.
- Potential for adverse effects on bone warrants further investigation.
Purpose of the Study:
- To review the existing literature on cyclosporine's effects on bone.
- To evaluate the evidence for cyclosporine-induced bone resorption.
- To identify potential strategies for mitigating adverse bone effects.
Main Methods:
- Systematic review of animal and human studies.
- Analysis of data on bone turnover markers.
- Evaluation of clinical outcomes related to bone health.
Main Results:
- Evidence suggests cyclosporine can increase bone turnover and favor resorption.
- Conflicting data exists regarding the dose-dependency and toxicity threshold.
- Most studies indicate a potential deleterious effect on bone is plausible.
Conclusions:
- Cyclosporine's effect on bone is a significant concern, despite contradictory findings.
- No specific counteracting agent is currently established.
- General bone health recommendations are advised for patients on cyclosporine.
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